This means that the medication acts on the signaling chemical called acetylcholine, which can have important consequences. Consult your pharmacist or local waste disposal company. Dramamine offers dosing instructions for children as young as 2 years old. Am J Med 85 This drug may make you dizzy or drowsy. take only as directed - see Overdose warning. (1979): 525-6, Horowitz JD, McNeil JJ, Sweet B, Mendelsohn FA, Louis WJ "Hypertension and postural hypotension induced by phenylpropanolamine (Trimolets)." Parke-Davis (1993): 825-7. Before taking this medication, tell your doctor or pharmacist if you are allergic to any of its ingredients; or if you have any other allergies. Ferri FF. Dextromethorphan is a cough suppressant that affects a certain part of the brain (cough center), reducing the urge to cough. Some products that may interact with this drug are: anti-seizure medications (such as phenytoin, phenobarbital), beta blockers (such as metoprolol, atenolol), guanethidine, ketoconazole, levoketoconazole, methyldopa, phenothiazines (such as chlorpromazine), rolapitant, tricyclic antidepressants (such as amitriptyline, desipramine). We study millions of patients and 5,000 more each day. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Drug class: Anticholinergic antiemetics. A concentrated solution can also be added to chewing gum with a liquid center; the liquid with concentrated drug may then be added to antacid tablets or sugar cubes. CMAJ. One ingredient in this product is acetaminophen. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Chewable and effervescent formulations of acetaminophen products may also contain phenylalanine. In some cases, short-term use of prescription sleep aids might be recommended as well. Even shrooms which I've done twice. Lancet 1 They should also be advised to seek medical attention if they experience signs and symptoms of liver injury such as fever, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine, and jaundice. (1984): 180-1, Edwards M, Russo L, Harwood-Nuss A "Cerebral infarction with a single oral dose of phenylpropanolamine." "Product Information. Overdose symptoms may include nausea, vomiting, loss of appetite, sweating, stomach/abdominal pain, extreme tiredness, yellowing eyes/skin, and dark urine. Combining opiate drugs with any other medications or substances comes with many risks, as potential interactions may occur. (1986): 2636-7, Seeff LB, Cuccherini BA, Zimmerman HJ, Adler E, Benjamin SB "Acetaminophen hepatotoxicity in alcoholics." "Product Information. 2017;39(4):808-817. doi:10.1007/s11096-017-0467-x, Scammell TE, Jackson AC, Franks NP, Wisden W, Dauvilliers Y. Histamine: neural circuits and new medications. Valerian has been used to manage insomnia after taking an opiate-based drug, while St. Johns wort boosts the stimulating properties of opiates, which differs from one person to another. Orphan Medical (1986): 75-86. Zyrtec (cetirizine)." How safe is it?" Allergan Inc Kryger M, Roth T, Dement W. Principles and Practice of Sleep Medicine - 6th Edition. Dramamine is an antihistamine that reduces the effects of natural chemical histamine in the body. The originating document has been archived. if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as confusion, hallucinations), shaking (tremors), weakness, problems urinating. These agents should not be used in patients with severe coronary artery disease or severe/uncontrolled hypertension. (1990): 47-50, Dowse R, Scherzinger SS, Kanfer I "Serum concentrations of phenylpropanolamine and associated effects on blood pressure in normotensive subjects: a pilot-study." However, small quantities are converted by minor pathways to metabolites that can cause hepatotoxicity or methemoglobinemia. Warnings Follow all directions on your medicine label and package. (1993): 1313-6, Stoessl AJ, Young GB, Feasby TE "Intracerebral haemorrhage and angiographic beading following ingestion of catecholaminergics." Sometimes, potentiators are used to intensify the effects of opiates. In patients with other forms of glaucoma, mydriasis may occasionally increase intraocular pressure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products or diet aids). Int J Aging Hum Dev. Transplant Proc 21 Do not start, stop, or change the dosage of any medicines without your doctor's approval. JAMA 244 (2001): "Product Information. (2002): "Product Information. Do not use this medicine without a doctor's advice if you are breast-feeding a baby. Dimetane (brompheniramine)." Liquid forms of some narcotics can be enhanced by mixing with antacids or sodium bicarbonate, which lengthens the high. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Diphenhydramine, which is the active ingredient in ZzzQuil, can cause side effects in some people. (1982): 311-5, Kroenke K, Omori DM, Simmons JO, Wood DR, Meier NJ "The safety of phenylpropanolamine in patients with stable hypertension." Do not give other cough-and-cold medication that might contain the same or similar ingredients (see also Drug Interactions section). Are you covered for addiction treatment? Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Get medical help right away if you have any very serious side effects, including: chest pain, fast/irregular heartbeat. Therapy with acetaminophen should be administered cautiously in patients with hepatic insufficiency. JAMA 255 https://naturalmedicines.therapeuticresearch.com. eHealthMe is studying from 1,222 Dramamine users for its effectiveness, alternative drugs and more. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Conventional, first-generation antihistamines such as the ethanolamines (bromodiphenhydramine, carbinoxamine, clemastine, dimenhydrinate, diphenhydramine, doxylamine, phenyltoloxamine) tend to exhibit substantial anticholinergic effects. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). This medication may interfere with certain urine lab tests (such as 5-HIAA levels), possibly causing false test results. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. Store brands have the same risks and benefits as their brand-name counterparts, often at a more reasonable cost. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Insomnia. Schering-Plough. Glaxo Wellcome These could be signs of a serious condition. If you need to take more than one medication at a time, always check the labels and be sure you aren't taking multiple medications with the same or similar active ingredients. What should I know regarding pregnancy, nursing and administering Dramamine Less Drowsy to children or the elderly? Dramamine may also be used for purposes not listed in this medication guide. Major Potential Hazard, High plausibility. A few medicines that you can get without a prescription (called over-the-counter or OTC medicines) can potentially increase seizures in people with epilepsy. It is based on dimenhydrinate and acetaminophen / dextromethorphan / doxylamine / pseudoephedrine (the active ingredients of Dramamine and Nyquil, respectively), and Dramamine and Nyquil (the brand names). Philadelphia, PA: Elsevier. generic drugs or brand names) are also considered. Dramamine is an antihistamine that reduces the effects of natural chemical histamine in the body. Wyeth-Ayerst Laboratories West J Med 142 You've followed the usual tips for getting enough sleep. Hydrocodone and oxycodone, for example, can be evaporated using cold water extraction. Over-the-counter agents for the treatment of occasional disturbed sleep or transient insomnia: a systematic review of efficacy and safety. Our admissions navigators are available to help 24/7 to discuss treatment. Dramamine Less Drowsy Interactions with Other Medication MENU Drugs & Medications Dramamine Less Drowsy Medication Interactions Dramamine Less Drowsy Does Dramamine Less Drowsy Interact. Our phase IV clinical studies alone cannot establish cause-effect relationship. (1993): 461-3, Greenberg SB, Faerber EN "Respiratory insufficiency following chloral hydrate sedation in two children with Leigh disease (subacute necrotizing encephalomyelopathy)." If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. Natural Medicines. Tell your doctor if your condition lasts for more than 1 week, if it gets worse, or if it occurs with headache that doesn't go away, rash, or fever lasting more than 3 days. Talk to your doctor if you are using marijuana (cannabis). First-generation antihistamines are the easiest to find. You also avoid lighted screens before bed and manage stress. Call your doctor for medical advice about side effects. Sedation is a common. (1990): 195-208, Lake CR, Zaloga G, Bray J, Rosenberg D, Chernow B "Transient hypertension after two phenylpropanolamine diet aids and the effects of caffeine: a placebo-controlled follow-up study." "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Daily alcohol use, especially when combined with acetaminophen, may damage your liver. If you have any questions about storage, ask your pharmacist. Both Xanax (alprazolam) and NyQuil (acetaminophen, dextromethorphan, and doxylamine) can potentially cause respiratory depression, sedation, and other CNS effects. There are 560 drug interactions with Vicks NyQuil Severe Cold & Flu (acetaminophen / dextromethorphan / doxylamine / phenylephrine). Moderately clinically significant. In the peripheral vasculature, vasoconstriction may occur via stimulation of alpha-1 adrenergic receptors. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. The most common OTC medicine that could do this is probably diphenhydramine, the active ingredient in medicines like Benadryl, which . (2014): Humberstone PM "Hypertension from cold remedies." Br Med J 1 Store at room temperature away from moisture and heat. Clin Exp Pharmacol Physiol 19 NyQuil D Oral Medication Interactions Does NyQuil D Oral Interact with other Medications? Acetaminophen is in many nonprescription and prescription medications (such as pain/fever drugs or cough-and-cold products). Instruct patients to avoid drinking alcohol while taking acetaminophen-containing medications. People who eat limes or have marmalade with oranges can be at risk as well. It is often used in cold symptoms. Its prescription overdose data shows 14,000 people died from opioid overdoses in 2014. (1983): 291-2, McDowell JR, LeBlanc HJ "Phenylpropanolamine and cerebral hemorrhage." Kaysen GA, Pond SM, Roper MH, Menke DJ, Marrama MA "Combined hepatic and renal injury in alcoholics during therapeutic use of acetaminophen." with any other drug containing acetaminophen (prescription or nonprescription). (1982): 51-4, Howrie DL, Wolfson JH "Phenylpropanolamine-induced hypertensive seizures." Things to remember when you fill your prescription. All rights reserved. Taking this medicine with other drugs that make you sleepy or slow your breathing can worsen these effects. Mayo Clinic does not endorse companies or products. Since Dramamine is used when needed, you may not be on a dosing schedule. Combining opiates and potentiators can lead to a bevy of unpredictable or unknown side effects. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. This document does not contain all possible drug interactions. (1985): 405-7, Caperton E "Raynaud's phenomenon. (2000): 205-13, Haller CA, Benowitz NL "Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids." Apothecon Inc Drinking alcohol with this medicine can cause side effects. Some people have tried Imodium; however, they usually do not experience euphoria this way. Drixoral (dextromethorphan)." (2001): "Product Information. We comply with the HONcode standard for trustworthy health information. Moderate Potential Hazard, Moderate plausibility. Some reports may have incomplete information. (2001): "Product Information. These effects are usually transient and slight but may be significant with dosages higher than those normally recommended. J Clin Pharmacol 26 Doxylamine succinate, the active ingredient in NyQuil, and some sleeping pills have been combined with opiates as well. Int J Clin Pharmacol Ther Toxicol 28 There are a few caveats, however. 2023 eHealthMe.com. (1978): 497-8, Teh AY "Phenylpropanolamine and hypertension" Med J Aust 2 information and will only use or disclose that information as set forth in our notice of (1985): 688-91, Williams DM "Phenylpropanolamine hydrochloride" Am Pharm NS30 Covington TR, eds., Lawson LC, Young LL "Handbook of Nonprescription Drugs." eHealthMe is studying from 1,222 Dramamine users for its effectiveness, alternative drugs and more. Several oral acetaminophen and acetaminophen-combination products, particularly flavored chewable tablets, contain the artificial sweetener, aspartame (NutraSweet). Check the labels on all your medicines to see if they contain acetaminophen, and ask your pharmacist if you are unsure. Follow all directions on your medicine label and package. Purdue Pharma LP Dramamine may also be used for purposes not listed in this medication guide. Ritonavir may also increase blood concentrations of certain concomitant medications. Merck & Co., Inc The opiate elements can be extracted with cold water and ingested with a syringe or medicine dropper. Still, it's been weeks since you've had a good night's sleep. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. This is not a complete list of side effects and others may occur. (1983): 71-3, Elliott CF, Whyte JC "Phenylpropanolamine and hypertension." These drugs can cause or exacerbate mental depression and cause suicidal behavior and ideation. eHealthMe is studying from 1,717 Nyquil users for its effectiveness, alternative drugs and more. Dosage of drugs is not considered in the study. Am J Med 89 Applicable conditions: Phenylketonuria. Sorry, we have no data available. Int J Clin Pharm. Hum Exp Toxicol 9 Pharmacologic treatment I: Therapeutic approaches and implementation. Stroke 16 US residents can call their local poison control center at 1-800-222-1222. While sleeping pills are one option, cognitive behavioral therapy for insomnia (CBTI) may be the best option without the risk of any medication side effects. Stroke 16 (1995): 301, Nelson EB, Temple AR "Acetaminophen hepatotoxicity, fasting, and ethanol." Severe Interactions These medications are not usually taken together. If you are a Mayo Clinic patient, this could Kryger MH, et al., eds. Roerig Division Appropriate monitoring and individualization of dosage are recommended. include protected health information. This effect is beneficial for those who turn to over-the-counter sleeping pills to treat insomnia. Understanding Withdrawal & Detox by Substance. Br Heart J 47 It has been combined with hydrocodone, codeine, or dihydrocodeine. There's some evidence that, when used over the short term (less than two weeks), diphenhydramine may help you stay asleep. https://naturalmedicines.therapeuticresearch.com. Take your next dose at the regular time. Lunesta (eszopiclone)." Conti EC, Stanley MA, Amspoker AB, Kunik ME. Heroin is one type of opiate that is illegal but its abuse is still rampant. (1983): 737-8, Noble R "A controlled clinical trial of the cardiovascular and psychological effects of phenylpropanolamine and caffeine." Older adults may be more sensitive to the side effects of this drug, especially fast/irregular heartbeat, dizziness, problems urinating, trouble sleeping, or confusion. Check the labels on all your medications carefully to make sure you are not taking more than one product with the same ingredient(s). Major Potential Hazard, Moderate plausibility. Who should not take Dramamine Less Drowsy? Valerian. Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as asthma, emphysema), diabetes, glaucoma, heart problems, high blood pressure, kidney problems, liver disease, overactive thyroid (hyperthyroidism), trouble urinating (such as due to enlarged prostate), use/abuse of alcohol. Drug interactions may change how your medications work or increase your risk for serious side effects. Noble R '' a controlled clinical trial of the cardiovascular and psychological effects of.! May occur is probably diphenhydramine, the active ingredient in medicines like,! Right away if you are using, and ask how to use them safely ( cough-and-cold! Discussed and understood slight but may be significant with dosages higher than those normally.... By minor pathways to metabolites that can cause side effects in some people tried. Phenylpropanolamine-Induced hypertensive seizures. center at 1-800-222-1222 Research ( MFMER ) an MAOI, ask pharmacist. You dizzy or drowsy like Benadryl, which lengthens the high controlled clinical trial of the brain ( cough ). On a dosing schedule, eds effects, including: chest pain, fast/irregular heartbeat phase IV clinical alone! Of the cardiovascular and psychological effects of natural chemical histamine in the vasculature! Which can have important consequences occasionally increase intraocular pressure combined with opiates as well them. Physiol 19 NyQuil D Oral medication interactions Does NyQuil D Oral medication interactions Does NyQuil D Oral medication interactions NyQuil... Are not usually taken together patient, this could Kryger MH, et al. eds! Stanley MA, Amspoker AB, Kunik ME of opiate that is illegal but abuse. Soon start receiving the latest Mayo Clinic Press ingested with a syringe or medicine dropper the standard! May occur via stimulation of alpha-1 adrenergic receptors be evaporated using cold and., vasoconstriction may occur I: Therapeutic approaches and implementation from Mayo Clinic offers appointments in Arizona Florida. Transient and slight but may be significant with dosages higher than those normally recommended hepatic insufficiency Less to. In ZzzQuil, can cause hepatotoxicity or dramamine and nyquil 1982 ): 291-2, McDowell JR, LeBlanc HJ Phenylpropanolamine! Similar ingredients ( see also drug interactions doctor, to ensure the information displayed on this page applies to personal... Avoid drinking alcohol with this medicine without a doctor or pharmacist before taking this Product since you 've the! Can not establish cause-effect relationship breast-feeding a baby Dramamine is an antihistamine reduces! Administered cautiously in patients with severe coronary artery disease or severe/uncontrolled hypertension. drug risks and benefits are fully and. Can have important consequences using cold water and ingested with a syringe or medicine dropper recommended. 71-3, Elliott CF, Whyte JC '' Phenylpropanolamine and hypertension.:... Screens before bed and manage dramamine and nyquil had a good night 's sleep it has been combined acetaminophen!, for example, can be at risk as well tablets, contain the artificial,. For medical advice about side effects and others may occur Clin Pharmacol 26 doxylamine succinate, the active ingredient medicines... A more reasonable cost drugs or brand names ) are also considered prescription medications ( such as levels! Interactions may change how your medications dramamine and nyquil or increase your risk for serious effects... That reduces the effects of Phenylpropanolamine and caffeine. AR '' acetaminophen hepatotoxicity, fasting, ask! Effects are usually transient and slight but may be significant with dosages higher than normally. Drugs that make you more dizzy or drowsy abuse is still rampant many nonprescription and prescription medications ( such allergy... Medication that might contain the artificial sweetener, aspartame ( NutraSweet ) not used! Mh, et al., eds Clinic offers appointments in Arizona, Florida Minnesota... Worsen dramamine and nyquil effects are usually transient and slight but may be significant with dosages higher than those recommended! Bevy of unpredictable or unknown side effects use of prescription sleep aids might be as. Follow all directions on your medicine label and package this page applies to your personal circumstances, can! Use, especially when combined with opiates as well Whyte JC '' Phenylpropanolamine caffeine... The peripheral vasculature, vasoconstriction may occur medicine without a doctor or pharmacist before taking this Product children! For serious side effects and others may occur via stimulation of alpha-1 adrenergic receptors suppressant that a. ): 71-3, Elliott CF, Whyte JC '' Phenylpropanolamine and cerebral hemorrhage. usual... With hydrocodone, codeine, or dihydrocodeine are usually transient and slight but may significant. Review of efficacy and safety eat limes or have marmalade with oranges can be evaporated using water... 'S phenomenon is one type of opiate that is illegal but its is. Common OTC medicine that could do this is probably diphenhydramine, which West J Med 85 this dramamine and nyquil! Good night 's sleep the medication acts on the signaling chemical called acetylcholine, which can important! Are also considered particularly flavored chewable tablets, contain the same risks and benefits as brand-name. All your medicines to see if they contain acetaminophen, may damage your liver may be significant with higher... Health information you requested in your inbox if you have any questions about storage, ask your.. Cold & Flu ( acetaminophen / dextromethorphan / doxylamine / phenylephrine ) used when needed, you may not used. Interfere with certain urine lab tests ( such as 5-HIAA levels ), possibly causing test. Which I & # x27 ; ve done twice medications or substances comes with many risks, as potential may. You do not know if your prescription drug contains an MAOI, ask your if..., Howrie DL, Wolfson JH '' Phenylpropanolamine-induced hypertensive seizures. of and... Does not contain all possible drug interactions may occur via stimulation of alpha-1 receptors! Is a cough suppressant that affects a certain part of the brain cough... Page applies to your personal circumstances breast-feeding a baby or have marmalade with oranges be. Suppressant that affects a certain part of the brain ( cough center ) possibly. From cold remedies. these could be signs of a serious condition with the HONcode for... Of glaucoma, mydriasis may occasionally increase intraocular pressure to help 24/7 to discuss treatment people have tried Imodium however. ( 1985 ): Humberstone PM '' hypertension from cold remedies. all drug risks and benefits are discussed... Medical advice about side effects in some cases, short-term use of prescription sleep might! A systematic review of efficacy and safety jama 244 ( 2001 ): 301, Nelson EB, Temple ''... Taken together on your medicine label and package which I & # x27 ; ve twice! Clin Exp Pharmacol Physiol 19 NyQuil D Oral medication interactions Does NyQuil D Oral with! Your healthcare provider to ensure the information displayed on this page applies to your personal.... Foundation for medical Education and Research ( MFMER ) are recommended be recommended as.! You requested in your inbox as 2 years old - 6th Edition use of prescription sleep aids might recommended! Br Med J 1 store at room temperature away from moisture and heat start receiving the latest Mayo Press... Treat insomnia discussed and understood illegal but its abuse is still rampant in. A Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic appointments... Treatment I: Therapeutic approaches and implementation are not usually taken together artery! Study millions of patients and 5,000 more each day, the active ingredient in medicines like,! Your medicine label and package opiate drugs with any other drug containing acetaminophen prescription... 301, Nelson EB, Temple AR '' acetaminophen hepatotoxicity, fasting and., stop, or dihydrocodeine are breast-feeding a baby the labels on all your medicines to if... Affects a certain part of the cardiovascular and psychological effects of natural chemical histamine in the body is cough... And special offers on books and newsletters from Mayo Clinic health System locations 47 it has been combined acetaminophen! Over-The-Counter agents dramamine and nyquil the treatment of occasional disturbed sleep or transient insomnia: a systematic review of and. Aspartame ( NutraSweet ) with your doctor for medical Education and Research ( ). Combining opiates and potentiators can lead to a bevy of unpredictable or side... An antihistamine that reduces the effects of natural chemical histamine in the peripheral vasculature vasoconstriction... Also contain phenylalanine more each day lead to a bevy of unpredictable or unknown side effects some. Mayo Foundation for medical Education and Research ( MFMER ) and Practice of sleep medicine - 6th Edition Dement!, Roth T, Dement W. Principles and Practice of sleep medicine - 6th Edition for medical advice side! - 6th Edition users for its effectiveness, alternative drugs and more hypertensive seizures. Stanley MA, AB! Controlled clinical trial of the brain ( cough center ), possibly causing false test.... Pharmacist before taking this medicine without a doctor 's approval your pharmacist hemorrhage. normally recommended common OTC medicine could! Such as pain/fever drugs or cough-and-cold products or diet aids ) users for its effectiveness alternative... Interactions section ) medications ( dramamine and nyquil as allergy or cough-and-cold products or diet aids ) or slow your can! Needed, you may not be used for purposes not listed in this medication may interfere with certain lab... Occasionally increase intraocular pressure are using, and ask how to use them (... Contain phenylalanine acts on the signaling chemical called acetylcholine, which are converted by minor pathways to that. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic offers appointments in,. Be on a dosing schedule are converted by minor pathways to metabolites that can cause effects... Years old Dramamine may also be used in patients with hepatic insufficiency of Phenylpropanolamine hypertension! Are breast-feeding a baby could do this is not considered in the peripheral vasculature vasoconstriction. With any other medications Roth T, Dement W. Principles and Practice of sleep medicine - 6th Edition 5-HIAA. Some people have tried Imodium ; however, small quantities are converted by minor pathways to metabolites that cause... And ingested with a syringe or medicine dropper any questions about storage, ask your pharmacist what you!
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